Nozaki-Renard J
Ann Microbiol (Paris). 1978 May-Jun;129(4):525-43.
Although it is generally admitted that Gram-positive bacteria cannot induce interferon, we were able to show that organisms and cell walls of Bacillis subtilis as well as components obtained through the extraction of endotoxins from Gram-negative bacteria can induce type II interferon. Moreover we have ascertained that those components have the same biological activity as the endotoxins, espcially with regard to their behaviour with B cells of lymphocytes, the results of pyrogen test, the incidence of cycloheximide and their function as inhibitors of bacteriophages. However, it has appeared that chemically they are quite different from the lipopolysaccharide of the Gram-negative bacteria: no lipid A could be detected.
尽管人们普遍认为革兰氏阳性菌不能诱导干扰素，但我们能够证明，枯草芽孢杆菌的菌体和细胞壁以及从革兰氏阴性菌中提取内毒素所获得的成分能够诱导Ⅱ型干扰素。此外，我们已经确定，这些成分具有与内毒素相同的生物学活性，特别是在它们与淋巴细胞的B细胞的相互作用、热原试验结果、放线菌酮的影响以及它们作为噬菌体抑制剂的功能方面。然而，已经发现它们在化学组成上与革兰氏阴性菌的脂多糖有很大不同：未检测到脂质A。
