Jerger J, Mauldin L, Igarashi M
Arch Otolaryngol. 1978 Oct;104(10):559-63. doi: 10.1001/archotol.1978.00790100013003.
Acoustic reflex thresholds for pure tones and broad-band noise were measured before and after treatment of nine squirrel monkeys. Experimental sensorineural hearing loss was created in six monkeys by ototoxic drug administration (gentamicin) and in three monkeys by exposure to intense sound. Extent of cochlear damage was assessed histopathologically, in the case of permanent loss induced by the ototoxic agent, and inferred from exposure history, in the case of the reversible loss induced by exposure to intense sound. Posttreatment changes in relationships among acoustic reflex thresholds (noise-tone difference [NTD]) reflected approximate degree of cochlear damage. Serial measurement of changes in the NTD in acoustic reflex thresholds appears to be a worthwhile and useful technique for monitoring sensorineural levels in the squirrel monkey.
在对九只松鼠猴进行治疗前后，测量了它们对纯音和宽带噪声的听觉反射阈值。通过耳毒性药物给药（庆大霉素）在六只猴子中造成了实验性感音神经性听力损失，通过暴露于高强度声音在三只猴子中造成了这种损失。对于由耳毒性药物引起的永久性听力损失，通过组织病理学评估耳蜗损伤程度；对于由暴露于高强度声音引起的可逆性听力损失，则根据暴露史推断损伤程度。治疗后听觉反射阈值之间关系的变化（噪声-纯音差值 [NTD]）反映了耳蜗损伤的大致程度。对听觉反射阈值中 NTD 变化的连续测量似乎是监测松鼠猴感音神经水平的一项有价值且有用的技术。
