Guard O, Renaud B, Chazot G
Encephale. 1976;2(4):293-303.
A study of the cerebral metabolism of dopamine and serotonin has been realized by the probenecid test in 17 patients. The diagnosis of Alzheimer's disease (13 patients) and Pick's disease (4 patients) has been made on clinical and radiological grounds. No important anomaly of this metabolism was discovered. In subjects with Alzheimer's disease, the renewal rates of H.V.A. and 5 H.I.A.A. were diminished in comparison to the values measured in normal individuals, but this difference was not significant. In patients with Pick's disease, the accumulation of H.V.A. after probenecid was in the normal bounds, whereas that of 5 H.I.A.A. was non-significantly decreased. The results are compared with those of the literature.
通过丙磺舒试验对17例患者的大脑多巴胺和血清素代谢进行了研究。基于临床和放射学依据诊断出阿尔茨海默病患者13例，皮克病患者4例。未发现这种代谢有重要异常。在阿尔茨海默病患者中，与正常个体测得的值相比，高香草酸（H.V.A.）和5-羟吲哚乙酸（5 H.I.A.A.）的更新率降低，但这种差异不显著。在皮克病患者中，丙磺舒给药后高香草酸的蓄积在正常范围内，而5-羟吲哚乙酸的蓄积则无显著降低。将结果与文献中的结果进行了比较。
