Szelies B, Karenberg A
Fortschr Neurol Psychiatr. 1986 Dec;54(12):393-7. doi: 10.1055/s-2007-1001944.
A clinically diagnosed case of advanced Pick's disease served to illustrate that positron emission tomography is a sensitive method for diagnosing complex functional disturbances. Pick's disease can be differentiated against presenile dementia represented by Alzheimer's disease in that the pattern of reduced metabolism characteristic of Alzheimer's disease is different from that of Pick's disease where in accordance with the clinical syndrome the glucose metabolism in the frontal and temporobasal regions in reduced, involving also the structures of the hippocampus and an equally significant reduction of glucose metabolism in the caudate nucleus. Especially during the initial phase of the disease when structural changes are not yet evident or the clinical manifestation of the syndrome does not correlate with the degree of lobar atrophy seen in the computer tomogram or via magnetic resonance tomography, positron emission tomography can make differential diagnosis much easier.
一例临床诊断为晚期匹克氏病的病例表明，正电子发射断层扫描是诊断复杂功能障碍的一种灵敏方法。匹克氏病可与以阿尔茨海默病为代表的早老性痴呆相鉴别，因为阿尔茨海默病特征性的代谢降低模式与匹克氏病不同，在匹克氏病中，根据临床综合征，额叶和颞叶底部区域的葡萄糖代谢降低，还累及海马结构，尾状核的葡萄糖代谢也同样显著降低。特别是在疾病的初始阶段，当结构变化尚不明显或综合征的临床表现与计算机断层扫描或磁共振断层扫描所见的脑叶萎缩程度不相关时，正电子发射断层扫描可使鉴别诊断容易得多。
