Lenney W, Milner A D, Tyler R M
Br J Dis Chest. 1978 Jul;72(3):225-30. doi: 10.1016/0007-0971(78)90046-3.
A double-blind controlled exercise challenge study has been performed in 16 asthmatic chlidren to show the effectiveness of BRL10833 in inhibiting exercise-induced bronchoconstriction. The children attended the respiratory laboratory on four occasions within the space of two weeks; on each occassion a routine 6-min exercise test was performed. At the first visit no drugs were given before the exercise test and all the children demonstrated abnormal exercise-induced bronchoconstriction as measured by peak expiratory flow rate (PEFR), forced expiratory volume in 1 sec (FEV1) and forced vital capacity (FVC). On the other three occasions the children were given sodium cromoglycate, BRL10833 or placebo medications before the exercise test. After sodium cromoglycate administration four children showed complete blocking and four showed partial blocking of exercise-induced bronchoconstriction. After BRL10833 four children showed complete blocking and six showed partial blocking of exercise induced bronchoconstriction. Placebo administration produced complete blocking of exercise-induced bronchoconstriction in three and partial blocking in two children. The results indicated that BRL10833 was almost as effective as sodium cromoglycate in inhibiting exercise-induced bronchoconstriction and placebo, although less effective than the two preparations, did afford protection from exercise-induced bronchoconstriction in some of the children.
一项双盲对照运动激发研究在16名哮喘儿童中进行，以显示BRL10833在抑制运动诱发的支气管收缩方面的有效性。这些儿童在两周内四次前往呼吸实验室；每次都进行常规的6分钟运动测试。在第一次就诊时，运动测试前未给药，所有儿童通过呼气峰值流速（PEFR）、一秒用力呼气量（FEV1）和用力肺活量（FVC）测量均显示出异常的运动诱发支气管收缩。在另外三次就诊时，儿童在运动测试前分别给予色甘酸钠、BRL10833或安慰剂药物。给予色甘酸钠后，四名儿童显示运动诱发支气管收缩完全被阻断，四名儿童显示部分被阻断。给予BRL10833后，四名儿童显示运动诱发支气管收缩完全被阻断，六名儿童显示部分被阻断。给予安慰剂后，三名儿童运动诱发支气管收缩完全被阻断，两名儿童部分被阻断。结果表明，BRL10833在抑制运动诱发支气管收缩方面几乎与色甘酸钠一样有效，而安慰剂虽然比这两种制剂效果差，但确实能在一些儿童中预防运动诱发的支气管收缩。
