Lampert F, Lau B
Eur J Pediatr. 1976 Dec 9;124(1):65-71. doi: 10.1007/BF00452416.
Within a 2-year period, from March 1974 until May 1976 10 patients with anorexia nervosa were seen at the children's university hospitals of München (2 patients) and Giessen (8 patients). The patients were 10-16 years old, with one exception all girls, and had the typical cachexia, hypothermia, bradycardia, gray, hairy skin, and amenorrhea in those who had reached menarche. The blood counts at diagnosis revealed a leukopenia (below 5000/mm3) in 6 patients and a thrombocytopenia (below 150000/mm3) in 4 patients. The bone marrow was examined in 7 patients and showed marked hypocellularity with only few megakaryocytes present and abundant vacuolated hyaline material. Bone marrow erythroblasts were decreased (below 20%) in 5 patients, although peripheral blood hemoglobin and hematocrit were normal or even elevated in all 10 patients. In 7 patients blood urea nitrogen was elevated above 30 mg%, the highest value being 145 mg%. Blood and bone marrow alterations as well as the renal abnormalities disappeared within days to a few weeks after a regimen of strict fluid and caloric intake was initiated and a gain in body weight of up to 10 kg was achieved.
在1974年3月至1976年5月的两年时间里，慕尼黑（2例）和吉森（8例）的大学儿童医院共接诊了10例神经性厌食症患者。患者年龄在10至16岁之间，除1例为男孩外，其余均为女孩，且均有典型的恶病质、体温过低、心动过缓、皮肤灰暗多毛，已初潮者出现闭经。诊断时的血常规检查显示，6例患者白细胞减少（低于5000/mm³），4例患者血小板减少（低于150000/mm³）。对7例患者进行了骨髓检查，结果显示骨髓细胞显著减少，仅见少量巨核细胞，并有大量空泡化透明物质。5例患者骨髓成红细胞减少（低于20%），尽管所有10例患者外周血血红蛋白和血细胞比容正常甚至升高。7例患者血尿素氮升高至30mg%以上，最高值为145mg%。在开始严格控制液体和热量摄入并使体重增加高达10kg的治疗方案后，血液和骨髓改变以及肾脏异常在数天至数周内消失。
