Bylund A C, Hammarsten J, Holm J, Scherstén T
Eur J Clin Invest. 1976 Nov 30;6(6):425-9. doi: 10.1111/j.1365-2362.1976.tb00538.x.
The enzyme pattern in gastrocnemius muscle tissue was studied in 39 patients with peripheral arterial insufficiency. Phosphofructokinase and glucose-6-phosphate-dehydrogenase were significantly increased in the skeletal muscles from these patients. The most pronounced changes were found in 3-OH-acyl-CoA-dehydrogenase, citrate synthase, and in cytochrome-c-oxidase. These enzyme activities were increased by 60, 40 and 25 per cent respectively. In patients with claudication as the only symptom, the metabolic capacity was generally increased in skeletal muscles affected by the low blood flow. With increasing severity of arterial insufficiency, all enzyme activities decreased and glycolytic enzymes were affected first. 3-OH-acyl-CoA-dehydrogenase, citrate synthase and cytochrome-c-oxidase activities were still comparatively high in patients with gangrenous foot ulcers, indicating some maintenance of the muscle viability even in situations with very low blood flow.
对39例外周动脉供血不足患者的腓肠肌组织酶谱进行了研究。这些患者骨骼肌中的磷酸果糖激酶和葡萄糖-6-磷酸脱氢酶显著增加。在3-羟基酰基辅酶A脱氢酶、柠檬酸合酶和细胞色素c氧化酶中发现了最明显的变化。这些酶的活性分别增加了60%、40%和25%。在仅以间歇性跛行为唯一症状的患者中，受低血流影响的骨骼肌的代谢能力通常会增加。随着动脉供血不足严重程度的增加，所有酶的活性均下降，糖酵解酶首先受到影响。在患有坏疽性足部溃疡的患者中，3-羟基酰基辅酶A脱氢酶、柠檬酸合酶和细胞色素c氧化酶的活性仍然相对较高，这表明即使在血流非常低的情况下，肌肉的活力仍能得到一定维持。
