Hodgson J E, Van Gorp P E
Fertil Steril. 1976 Dec;27(12):1359-65. doi: 10.1016/s0015-0282(16)42249-1.
Midtrimester abortion was successfully induced in 55 of 60 patients with continuous extraovular infusion of prostaglandin F2alpha (PGF2alpha) following the insertion of intracervical laminaria tents. Intravenous oxytocin was also used in 38 (63%) of the 60 patients. The mean induction-abortion time (IAT) was 11.72 hours +/- 1.06 SD). Abortion was completed in 40% within 8 hours, 80% within 16 hours, and 93% within 24 hours. The mean total dose of PGF2alpha was 41.9 mg. There was no significant difference in IAT between the parous patients (13.40 hours +/- 1.90 SD) and the nulliparous patients (10.41 hours +/- 1.13 SD). There was no apparent correlation between IAT and the stages of gestation (12 to 22 weeks). The five patients who failed to abort within 24 to 36 hours underwent uterine evacuation, which was easily accomplished because there was a marked degree of cervical dilatation. Side effects and complications of the technique were few. Endometritis occurred in three patients, two of whom had had intrauterine devices in situ until just prior to the procedure. It appears that this method has a high success rate, an acceptable safety factor, good patient tolerance, and relatively few side effects.
在60例患者中，于宫颈内插入海藻棒后持续经卵膜外输注前列腺素F2α（PGF2α），成功诱导了55例中期妊娠流产。60例患者中有38例（63%）还使用了静脉缩宫素。平均引产-流产时间（IAT）为11.72小时±1.06标准差。40%的患者在8小时内完成流产，80%在16小时内完成，93%在24小时内完成。PGF2α的平均总剂量为41.9毫克。经产妇（13.40小时±1.90标准差）和未产妇（10.41小时±1.13标准差）的IAT无显著差异。IAT与妊娠阶段（12至22周）之间无明显相关性。24至36小时内未流产的5例患者接受了清宫术，由于宫颈有明显扩张，清宫术很容易完成。该技术的副作用和并发症较少。3例患者发生子宫内膜炎，其中2例在手术前一直放置宫内节育器。看来这种方法成功率高、安全系数可接受、患者耐受性好且副作用相对较少。
