Ludvigsson J, Heding L G
Diabetologia. 1976 Dec;12(6):627-30. doi: 10.1007/BF01220642.
Serum C-peptide, insulin-binding IgG and total insulin (IRI) were determined in 96 juvenile diabetics aged 4-21 years, with onset of diabetes at the age of 1-16 years and with 2-17 years' duration of diabetes. Thirty-four patients (35.4%) had detectable levels of C-peptide (greater than or equal to 0.04 pmol/ml). Compared to non-diabetic adults, 19 had values below the normal range, 12 showed values within the normal range (0.18-0.63 pmol/ml) and 3 rated above normal. There was a negative correlation between the fasting C-peptide concentration and the degree of ketonuria at the onset of diabetes and a positive correlation between C-peptide levels and the incidence of post-initial remission periods. Patients without detectable C-peptide had significantly higher levels of insulin antibodies than those who had detectable levels of C-peptide. The possibility of a relationship between the intensity of the initial treatment of diabetes and the preservation of the B-cell function is discussed, as well as the possibility of insulin antibodies being a cause of B-cell exhaustion.
对96名4至21岁的青少年糖尿病患者进行了血清C肽、胰岛素结合IgG和总胰岛素（IRI）检测，这些患者糖尿病发病年龄在1至16岁之间，病程为2至17年。34名患者（35.4%）C肽水平可检测到（大于或等于0.04 pmol/ml）。与非糖尿病成年人相比，19人的数值低于正常范围，12人显示数值在正常范围内（0.18 - 0.63 pmol/ml），3人高于正常范围。糖尿病发病时空腹C肽浓度与酮尿程度呈负相关，C肽水平与初始缓解期后的发生率呈正相关。未检测到C肽的患者胰岛素抗体水平显著高于检测到C肽的患者。讨论了糖尿病初始治疗强度与B细胞功能保存之间关系的可能性，以及胰岛素抗体成为B细胞耗竭原因的可能性。
