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感觉差异阻滞:利多卡因用于脊髓麻醉与硬膜外麻醉的比较

Differential sensory block: spinal vs epidural with lidocaine.

作者信息

White J L, Stevens R A, Kao T C

机构信息

Department of Anesthesiology, Georgetown University Medical Center, Washington, D.C., USA.

出版信息

Can J Anaesth. 1998 Nov;45(11):1049-53. doi: 10.1007/BF03012390.

Abstract

PURPOSE

In this study we sought to determine if and when a difference exists with regards to differential sensory blockade between spinal and epidural anaesthesia using lidocaine.

METHODS

Ten healthy volunteers were randomly assigned to receive both spinal and epidural anaesthesia. Non-epinephrine containing solutions of lidocaine, 100 mg lidocaine 5% with 7.5% dextrose (spinal) and 600 mg lidocaine 2% (epidural), were used to establish sensory blockade. At five minute intervals, for a total of 65 min, the following sensory modalities were tested: anaesthesia (complete loss of sensation to pinprick), analgesia (loss of an equally sharp sensation to pinprick compared with that at an unblocked dermatome), cold sensation (complete loss of cold temperature discrimination).

RESULTS

At all times, except at time = 0 during spinal anaesthesia, the levels of analgesia and cold sensation were more cephalad than the level of anaesthesia for both spinal and epidural anaesthesia. Multiple comparison testing among the three dermatomal response levels showed that, during epidural anaesthesia, the level of analgesia was more cephalad than the level of cold sensation at the following times: 25 min, 30 min, and from 40 to 60 min. In contrast, the level of analgesia was not different from the level of cold sensation during spinal anaesthesia.

CONCLUSIONS

Spinal and epidural anaesthesia with lidocaine produce a similar degree of differential sensory blockade. Epidural anaesthesia produces a detectable difference between the level of analgesia and cold sensation at various times, whereas spinal anaesthesia did not reliably do so in this study.

摘要

目的

在本研究中,我们试图确定使用利多卡因时,脊髓麻醉和硬膜外麻醉在感觉阻滞差异方面是否存在差异以及何时存在差异。

方法

10名健康志愿者被随机分配接受脊髓麻醉和硬膜外麻醉。使用不含肾上腺素的利多卡因溶液,100mg 5%利多卡因与7.5%葡萄糖(脊髓麻醉)和600mg 2%利多卡因(硬膜外麻醉)来建立感觉阻滞。每隔5分钟,共65分钟,测试以下感觉模式:麻醉(对针刺完全失去感觉)、镇痛(与未阻滞的皮节相比,对针刺的尖锐感觉丧失)、冷觉(冷温度辨别完全丧失)。

结果

在所有时间,除了脊髓麻醉开始时(时间=0),脊髓麻醉和硬膜外麻醉的镇痛和冷觉水平均比麻醉水平更靠头侧。对三个皮节反应水平进行多重比较测试表明,在硬膜外麻醉期间,在以下时间镇痛水平比冷觉水平更靠头侧:25分钟、30分钟以及40至60分钟。相比之下,脊髓麻醉期间镇痛水平与冷觉水平无差异。

结论

利多卡因脊髓麻醉和硬膜外麻醉产生相似程度的感觉阻滞差异。硬膜外麻醉在不同时间的镇痛水平和冷觉水平之间产生了可检测到的差异,而在本研究中脊髓麻醉未可靠地产生这种差异。

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