Gire C, Minodier P, Di Marco J N, Adiceam P, Palix C, Chau C, Potier A, Boubli L
Service de Pédiatrie et de Néonatologie, Hôpital Mère-Enfant, Marseille.
J Gynecol Obstet Biol Reprod (Paris). 1998 Dec;27(8):811-3.
We report on a case of fetal goitrous diagnosed on ultrasonogram done at 31 weeks of gestation. Thyroid maternal function was normal and no therapeutic was responsible. Hormonal test done on cord blood supported diagnosis of prenatal hypothyroidism. The infant was born prematurely at gestation age of 34 without antenatal treatment. He was eutrophic with clinical and biological signs of hypothyroidism and a large goiter. Therapy with thyroxine was instituted on the third day of life. At 9 months, growth and development are normal. Congenital hypothyroidism has an incidence of approximately 1 in every 4000-5000 live births. Rarely fetal goitrous hypothyroidism have been attributed to thyroid hormone dyshormonogenesis. When fetal goiter is diagnosed on ultrasonography, without maternal hypothyroidism or therapeutic and when hypothyroidism is confirmed on fetal blood, this diagnosis must be suspected.
我们报告一例在妊娠31周时超声检查诊断出的胎儿甲状腺肿病例。母亲甲状腺功能正常，无治疗相关因素。脐血激素检测支持产前甲状腺功能减退的诊断。该婴儿在孕34周时早产，未接受产前治疗。他营养良好，有甲状腺功能减退的临床和生物学体征以及一个大甲状腺肿。出生第三天开始使用甲状腺素治疗。9个月时，生长发育正常。先天性甲状腺功能减退症的发病率约为每4000 - 5000例活产中有1例。胎儿甲状腺肿性甲状腺功能减退症很少归因于甲状腺激素合成障碍。当超声检查诊断出胎儿甲状腺肿，而母亲无甲状腺功能减退或治疗相关因素且胎儿血液证实有甲状腺功能减退时，必须怀疑此诊断。
