Dollar J R, Boots L R, Bagwell J N
Cell Tissue Res. 1978 Sep 26;192(3):451-60. doi: 10.1007/BF00212325.
Endometrium from a group of baboons treated with the oral contraceptive, Enovid E, was studied histologically, histochemically and ultrastructurally, and compared to endometrium from normally cycling animals. All endometria were obtained by transcervical uterine biopsy between 10 and 14 days of the treatment cycle or the normal menstrual cycle. Histologically, no discernible differences between the control and experimental endometria were apparent. While observable differences were not evident between the endometrial alkaline phosphatase and succinate dehydrogenase activities of control and experimental animals, there was an increased acid phosphatase activity in the Enovid E-treated baboon endometrium. Ultrastructurally, the glandular cells of treated animals appeared to be more physiologically advanced than did those from the control endometria. These advances were evident from the prominent Golgi complex, increased development of the endoplasmic reticulum and increases in the size, number and complexity of mitochondria. The functional correlates of these morphological and histochemical observations are discussed and compared to human endometrial studies.
对一组接受口服避孕药炔雌醇甲醚（Enovid E）治疗的狒狒的子宫内膜进行了组织学、组织化学和超微结构研究，并与正常月经周期动物的子宫内膜进行了比较。所有子宫内膜均在治疗周期或正常月经周期的第10至14天通过经宫颈子宫活检获取。组织学上，对照和实验性子宫内膜之间没有明显差异。虽然对照和实验动物的子宫内膜碱性磷酸酶和琥珀酸脱氢酶活性之间没有明显的可观察到的差异，但在接受炔雌醇甲醚治疗的狒狒子宫内膜中酸性磷酸酶活性增加。超微结构上，治疗动物的腺细胞在生理上似乎比对照子宫内膜的腺细胞更成熟。这些进展从突出的高尔基体复合体、内质网的发育增加以及线粒体的大小、数量和复杂性增加中明显可见。讨论了这些形态学和组织化学观察结果的功能相关性，并与人类子宫内膜研究进行了比较。
