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作为研究子宫内膜的灵长类动物模型的狒狒。

The baboon as a primate model for the study of endometrium.

作者信息

Dollar J R, Hand G S, Beck L R, Boots L R

出版信息

Am J Obstet Gynecol. 1979 Jun 1;134(3):305-9. doi: 10.1016/s0002-9378(16)33037-x.

DOI:10.1016/s0002-9378(16)33037-x
PMID:110149
Abstract

A series of transcervical uterine biopsy specimens were obtained at various stages of the menstrual cycle from a colony of 11 normally cycling female baboons, Papio anubis and Papio cynocephalus. Morphologically, baboon endometrium appeared to be similar to human endometrium. Alkaline phosphatase activity was maximal throughout the preovulatory phase and during the late postovulatory period. During the preovulatory phase acid phosphatase was not demonstrable but increased after ovulation to reach maximal activity prior to menstruation. While differences exist between human and baboon endometria, the overall morphologic and histochemical changes are similar. In addition, the baboon's endometrium is readily accessible by transcervical uterine biopsy, thus making these animals valuable primate models for study of human reproductive problems.

摘要

从11只正常月经周期的雌性狒狒(埃及狒狒和东非狒狒)群体中,在月经周期的不同阶段获取了一系列经宫颈子宫活检标本。形态学上,狒狒的子宫内膜似乎与人类子宫内膜相似。碱性磷酸酶活性在整个排卵前期和排卵后期后期最高。在排卵前期,酸性磷酸酶无法检测到,但在排卵后增加,在月经前达到最大活性。虽然人类和狒狒的子宫内膜存在差异,但总体形态学和组织化学变化相似。此外,狒狒的子宫内膜可通过经宫颈子宫活检轻易获取,因此使这些动物成为研究人类生殖问题的有价值的灵长类动物模型。

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