Bluet-Pajot M T, Schaub C
C R Acad Hebd Seances Acad Sci D. 1978 Jun 12;286(23):1707-10.
The authors investigated basal levels of plasma immunoreactive growth-hormone in the rat (R-GH) after administration of 3 different anesthetic drugs: urethan, chloral hydrate and gamma-hdroxy-butyrate (GHB). Lowest R-GH concentrations (5 +/- 3 ng/ml) are observed after urethan; they are significantly higher (15 +/- 4 ng/ml) after chloral hydrate but this anesthetic also causes hyperglycemia (210 +/- 30 mg/100 ml). Normal blood glucose levels are observed under GHB narco-analgesia which elicits a clear-cut R-GH secretory episode (70 +/- 5 ng/ml); basal values (12 +/- 3 ng/ml) are maintained for several hours thereafter.
作者研究了给大鼠注射三种不同麻醉药物（氨基甲酸乙酯、水合氯醛和γ-羟基丁酸盐，即GHB）后血浆免疫反应性生长激素（R-GH）的基础水平。氨基甲酸乙酯注射后观察到最低的R-GH浓度（5±3纳克/毫升）；水合氯醛注射后浓度显著更高（15±4纳克/毫升），但这种麻醉剂也会导致高血糖（210±30毫克/100毫升）。在GHB麻醉镇痛下观察到正常血糖水平，这引发了明显的R-GH分泌高峰（70±5纳克/毫升）；此后数小时维持基础值（12±3纳克/毫升）。
