Bluet-Pajot M T, Schaub C, Nassiet J
Neuroendocrinology. 1978;26(3):141-9. doi: 10.1159/000122776.
Plasma immuno-reactive growth-hormone (RIA-GH) concentrations were investigated under in vivo continuous blood glucose (BG) monitoring after administration of gamma-hydroxybutyrate (GHB) as well as during spontaneous or insulin-induced hypoglycemia. During the narco-analgesia by GHB a marked secretory episode is consistently observed. This secretion peak is not accurately time related with GHB administration and seems to fade off in aging animals. Strictly controlled hypoglycemia elicits a consistent and specific GH release. In contrast deep hypoglycemic levels resulting in a state of metabolic stress inhibit GH secretion. Our results suggest that previous data on the GH regulation pattern during hypoglycemia may depend upon the anesthetic used and/or nonspecific stress responses following deep hypoglycemia. The above mentioned experimental conditions indicate that GH metabolic regulation is not fundamentally different in rodents and primates.
在给予γ-羟基丁酸（GHB）后进行体内连续血糖（BG）监测期间，以及在自发性或胰岛素诱导的低血糖期间，对血浆免疫反应性生长激素（RIA-GH）浓度进行了研究。在GHB诱导的麻醉镇痛期间，始终观察到明显的分泌高峰。该分泌峰值与GHB给药的时间关系不准确，并且在衰老动物中似乎会逐渐消失。严格控制的低血糖会引发持续且特定的生长激素释放。相比之下，导致代谢应激状态的深度低血糖水平会抑制生长激素分泌。我们的结果表明，先前关于低血糖期间生长激素调节模式的数据可能取决于所使用的麻醉剂和/或深度低血糖后的非特异性应激反应。上述实验条件表明，啮齿动物和灵长类动物的生长激素代谢调节在根本上没有差异。
