Roose S P, Devanand D, Suthers K
College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Geriatrics. 1999 Feb;54(2):20-1, 25-6, 29-31 passim.
Depressed patients develop symptomatic and fatal ischemic heart disease at a higher rate than nondepressed patients, even after studies are controlled for known cardiovascular risk factors. Changes in sympathetic and parasympathetic tone appear to make depressed patients more vulnerable to ventricular fibrillation. Tricyclic antidepressants share the electrophysiologic profile of type 1A antiarrhythmic compounds and therefore may carry a risk of increased mortality when given to patients with ischemic heart disease. Serotonin reuptake inhibitors have shown no antiarrhythmic effect in depressed patients with serious cardiovascular disease, but studies to date have been small and short-term.
与非抑郁症患者相比，抑郁症患者发生有症状的和致命性缺血性心脏病的几率更高，即使在研究中已对已知的心血管危险因素进行了控制。交感神经和副交感神经张力的变化似乎使抑郁症患者更容易发生心室颤动。三环类抗抑郁药具有1A类抗心律失常化合物的电生理特征，因此，给予缺血性心脏病患者时可能会有增加死亡率的风险。5-羟色胺再摄取抑制剂对患有严重心血管疾病的抑郁症患者未显示出抗心律失常作用，但迄今为止的研究规模小且为期短期。
