Glassman A H, Rodriguez A I, Shapiro P A
College of Physicians and Surgeons, Columbia University, New York, NY, USA.
J Clin Psychiatry. 1998;59 Suppl 10:16-21.
Both depression and cardiovascular disease are common as people age and are, therefore, likely to coexist. It has become evident recently that the rate of this comorbidity exceeds substantially what is expected by chance. A major problem arises in that there is increasing evidence that the tricyclic antidepressants (TCAs) carry more risk than originally thought in patients with ischemic heart disease. This risk increases the importance of understanding both the safety and efficacy of the serotonin selective reuptake inhibitors (SSRIs) in this population. Three recent studies on safety data in patients with overt heart disease are now available: although the total of 94 patients limits the ability to make generalizations, the data that are available give little evidence of harm and even suggest that SSRIs may have beneficial effects in ischemic heart disease.
随着人们年龄的增长，抑郁症和心血管疾病都很常见，因此很可能同时存在。最近已经很明显，这种共病率大大超过了偶然预期的水平。一个主要问题出现了，因为越来越多的证据表明，三环类抗抑郁药（TCA）在缺血性心脏病患者中所带来的风险比最初认为的要高。这种风险增加了了解5-羟色胺选择性再摄取抑制剂（SSRI）在该人群中的安全性和有效性的重要性。最近有三项关于明显心脏病患者安全性数据的研究：尽管总共94名患者限制了进行概括的能力，但现有数据几乎没有显示出危害的证据，甚至表明SSRI在缺血性心脏病中可能具有有益作用。
