Epstein H T, Newton J T, Fenton K
Biology Department, Brandeis University, Waltham, Mass., USA.
Biol Neonate. 1999;75(4):272-8. doi: 10.1159/000014104.
Target mice were nursed by mothers given lead starting (1) when target mice were born; (2) after conception of target mice, or (3) during the mothers' own pre-weaning age. These target mice are called, respectively, POSTNATAL, GESTATIONAL, and PRE-MATING. Compared to developments in control mice, postnatal lead slowed brain weight development, lowered asymptotic brain weight, decreased DNA per brain somewhat, but had no effect on protein per brain. Gestational lead similarly slowed brain weight development, lowered asymptotic brain weight, greatly decreased DNA per brain, but had no effect on protein per brain. In contrast, pre-mating lead significantly increased brain weight and protein per brain and lowered DNA per brain substantially. These effects of pre-mating lead on brain weight and protein per brain could be due to the effects of lead on developing maternal reproductive systems or to lead's presence during the rarely studied ovulation-to-fertilization period.
(1) 幼鼠出生时；(2) 幼鼠受孕后；或(3) 母鼠自身断奶前的时期。这些幼鼠分别称为产后、孕期和交配前暴露组。与对照小鼠的发育情况相比，产后暴露于铅会减缓脑重发育，降低渐近脑重，使每脑DNA略有减少，但对每脑蛋白质无影响。孕期暴露于铅同样会减缓脑重发育，降低渐近脑重，使每脑DNA大幅减少，但对每脑蛋白质无影响。相比之下，交配前暴露于铅会显著增加脑重和每脑蛋白质含量，并大幅降低每脑DNA含量。交配前暴露于铅对脑重和每脑蛋白质的这些影响可能是由于铅对发育中的母体生殖系统的影响，或者是由于在很少研究的排卵到受精期间铅的存在。
