Barkur Rajashekar Rao, Bairy Laxminarayana Kurady
Department of Biochemistry, Melaka Manipal Medical College, Manipal University, Manipal, Karnataka, India.
Biol Trace Elem Res. 2015 Apr;164(2):212-8. doi: 10.1007/s12011-014-0221-3. Epub 2015 Jan 10.
Epidemiological studies in children have proved that lead (Pb) exposure causes deficits in neural and cognitive functions. The present study assessed the oxidative stress on postnatal day 30, in the hippocampus, cerebellum and frontal cortex of rat pups exposed to Pb during specific periods of early brain development. Five groups of rat pups were investigated, and 0.2% Pb acetate in drinking was the dosage used. (i) Gestation and lactation (GL) group (n = 9) of rat pups was exposed to Pb during gestation and lactation through their mother, (ii) gestation (G) group (n = 9) of rat pups was exposed to Pb during gestation only, (iii) lactation (L) group (n = 9) of rat pups was exposed to Pb during lactation only, (iv) pre-gestation (PG) group (n = 9) of rat pups was born to mothers who were exposed to Pb for 1 month before conception, and (v) normal control (NC) (n = 9) group of rats pups had no exposure to Pb during gestation and lactation period. From the present study, it is evident that Pb exposure during different periods of early brain development (GL, G, L and PG groups) causes oxidative stress and lactation period (postnatal period) of Pb exposure produces maximum oxidative stress.
针对儿童的流行病学研究已证明，铅（Pb）暴露会导致神经和认知功能缺陷。本研究评估了在大脑早期发育的特定阶段暴露于铅的幼鼠在出生后第30天海马体、小脑和额叶皮质中的氧化应激情况。研究了五组幼鼠，使用的剂量是饮水中含0.2%醋酸铅。（i）妊娠和哺乳期（GL）组（n = 9）的幼鼠在妊娠和哺乳期通过其母亲接触铅，（ii）妊娠（G）组（n = 9）的幼鼠仅在妊娠期间接触铅，（iii）哺乳期（L）组（n = 9）的幼鼠仅在哺乳期接触铅，（iv）孕前（PG）组（n = 9）的幼鼠出生于在受孕前1个月接触铅的母亲，（v）正常对照（NC）组（n = 9）的幼鼠在妊娠和哺乳期未接触铅。从本研究可以明显看出，在大脑早期发育的不同阶段（GL、G、L和PG组）接触铅会导致氧化应激，且哺乳期（出生后阶段）接触铅会产生最大的氧化应激。
