X射线照射对青春期前和成年大鼠（褐家鼠）雌性生育能力及生殖细胞的影响。

Effects on female fertility and germinal cells in prepubertal and adult rats (Rattus norvegicus) after X-ray irradiation.

作者信息

Martínez-Flores I, Egozcue J, Garcia M

机构信息

Departament de Biologia Cellular i Fisiologia, Facultad de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain.

出版信息

Adv Exp Med Biol. 1998;444:215-9. doi: 10.1007/978-1-4899-0089-0_25.

DOI:10.1007/978-1-4899-0089-0_25

PMID:10026952

Abstract

In this work we analyse the effects of ionizing radiation in prepubertal and adult female rats, using as parameters, implantation sites, embryonic loss, and synaptonemal complex (SC) analysis of the female F1 of the pregnant rats. Our preliminary results show a decrease statistically significant in fertility of irradiated groups, but cytogenetic analysis did not shown any inherited damage attributed to radiation. At the same time, our results seem to indicate a higher resistance of oocytes from prepubertal rats and support the possible use of GnRH agonists as oestrus cycle suppressors to turn adult rats into gonadal quiescence.

摘要

在这项研究中，我们以植入部位、胚胎丢失以及对怀孕大鼠雌性F1代的联会复合体（SC）分析为参数，分析了电离辐射对青春期前和成年雌性大鼠的影响。我们的初步结果显示，受辐照组的生育力在统计学上有显著下降，但细胞遗传学分析未发现任何归因于辐射的遗传损伤。同时，我们的结果似乎表明青春期前大鼠的卵母细胞具有更高的抗性，并支持将促性腺激素释放激素（GnRH）激动剂作为发情周期抑制剂以使成年大鼠进入性腺静止状态的可能性。