电离辐射对青春期前受照大鼠卵母细胞的影响。
Effects of ionizing radiation on oocytes of prepubertally irradiated rats.
作者信息
Martínez-Flores I, Saez C, Egozcue J, Garcia M
机构信息
Departament de Biologia Cellular, Fisiologia i Immunologia, Unitat de Biologia, Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain.
出版信息
Int J Radiat Biol. 2000 Oct;76(10):1403-7. doi: 10.1080/09553000050151682.
PURPOSE
To characterize the effects of ionizing radiation on the immature oocytes of prepubertal rats aged 16-20 days old.
MATERIALS AND METHODS
The abdomen of Sprague Dawley (SD) female rats was exposed to 0, 1 and 2 Gy of X-rays. The effects were analysed when the animals became adults (80 days old) using as parameters the number of implantation sites, embryonic loss, dominant lethality and the synaptonemal complex (SC) analysis of F1 female foetuses.
RESULTS
A statistically significant decrease in the fertility of the 2 Gy irradiated rats was observed. However, the SC analysis of F1 female foetuses showed no cytogenetic damage that could be attributed to radiation.
CONCLUSIONS
A reproductive effect was demonstrated but no inherited genetic damage was detected by SC analysis in female foetuses of irradiated mothers.
目的
表征电离辐射对16 - 20日龄青春期前大鼠未成熟卵母细胞的影响。
材料与方法
将斯普拉格-道利（SD）雌性大鼠腹部暴露于0、1和2 Gy的X射线下。当动物成年（80日龄）时，以着床部位数量、胚胎丢失、显性致死率以及对F1雌性胎儿的联会复合体（SC）分析为参数，分析辐射影响。
结果
观察到接受2 Gy照射的大鼠生育力出现统计学显著下降。然而，对F1雌性胎儿的SC分析未显示可归因于辐射的细胞遗传学损伤。
结论
证实了辐射对生殖的影响，但通过SC分析在受照射母亲的雌性胎儿中未检测到遗传损伤。
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