Blazsó G, Rázga Z, Gábor M
Institute of Pharmacodynamics, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Fundam Clin Pharmacol. 1999;13(1):91-5. doi: 10.1111/j.1472-8206.1999.tb00325.x.
Experiments with male mice (28-32 g) of the CFLP strain showed that cinnarizine in doses of 2.5, 5.0 or 10.0 mg kg-1 significantly inhibited the extent of ear oedema induced by croton oil, capsaicin or dithranol, in a dose-dependent manner. In rats of the Wistar strain, oedema was induced in the hind paw by subplantar injection of carrageenin, and simultaneously by the application of croton oil to the inner surface of the ear. Preliminary cinnarizine treatment (5, 10 or 20 mg kg-1) inhibited the development of both types of oedema, to a statistically significant extent, in a dose-dependent manner.
对CFLP品系雄性小鼠（28 - 32克）进行的实验表明，剂量为2.5、5.0或10.0毫克/千克的桂利嗪能以剂量依赖的方式显著抑制巴豆油、辣椒素或地蒽酚诱导的耳部水肿程度。在Wistar品系大鼠中，通过足底注射角叉菜胶诱导后爪水肿，并同时在耳部内表面涂抹巴豆油。预先给予桂利嗪（5、10或20毫克/千克）能以剂量依赖的方式在统计学上显著抑制两种类型水肿的发展。
