桂利嗪的抗水肿作用
[Anti-edematous effects of cinnarizine].
作者信息
Rázga Z, Gábor M
机构信息
Szent-Györgyi Albert Orvostudományi Egyetem, Gyógyszerhatástani Intézet, Szeged.
出版信息
Acta Pharm Hung. 1993 Jan;63(1):35-9.
PMID:8452034
Abstract
Experiments carried out with male mice (28-32 g) of CFLP strain have shown that cinnarizine significantly inhibits the extents of ear oedema induced by croton oil or capsaicin. In rats of Wistar strain, oedema was induced in the hind paw by subplantar injection of carrageenin, and simultaneously by the application of croton oil to the inner surface on the ear. Preliminary cinnarizine treatment inhibited the development of both types of oedema, to statistically significant extent.
摘要
对CFLP品系雄性小鼠（28 - 32克）进行的实验表明，桂利嗪能显著抑制巴豆油或辣椒素诱导的耳部水肿程度。在Wistar品系大鼠中，通过足底注射角叉菜胶诱导后爪水肿，并同时在耳部内表面涂抹巴豆油。预先使用桂利嗪治疗可抑制两种类型水肿的发展，且具有统计学意义。
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