Salvadori B, Marubini E, Miceli R, Conti A R, Cusumano F, Andreola S, Zucali R, Veronesi U
Chirurgia Generale C, Istituto Nazionale per lo Studio e la Cura dei Tumori di Milano, Milan, Italy.
Br J Surg. 1999 Jan;86(1):84-7. doi: 10.1046/j.1365-2168.1999.00961.x.
This study aimed to analyse the possibility of surgical rescue of intrabreast tumour recurrence (IBTR) following conservative operation for breast cancer, i.e. quadrantectomy, axillary dissection and radiotherapy.
Of 2544 patients treated with this approach, 209 presented with an IBTR as the first and only sign of relapse. Some 197 patients were considered suitable for further surgery; 12 were inoperable. Six patients declined operation.
Reoperative surgery was total mastectomy in 134 patients (70 per cent) and further local resection in 57 (30 per cent). Median follow-up after second surgery was 73 (range 1-192) months. The overall survival probability at 60 months was 70 per cent after mastectomy and 85 per cent following further local excision. There was no difference in disease-free survival between the two operative groups. Second IBTR was more common at 5 years in the re-excision group (19 versus 4 per cent).
Since the type of surgery did not seem to affect survival, breast conservation can be considered in selected patients with IBTR.
