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使用兆伏级电子放射治疗的单束三维适形放疗技术，对乳房切除术后乳腺癌患者专用三维打印人体模型中治疗计划系统的剂量学评估。

Dosimetry Evaluation of Treatment Planning Systems in Patient-Specific 3D Printed Anthropomorphic Phantom for Breast Cancer after Mastectomy using a Single-Beam 3D-CRT Technique for Megavoltage Electron Radiation Therapy.

作者信息

Endarko Endarko, Aisyah Siti, Hariyanto Aditya Prayugo, Haekal Mohammad, Kavilani Nandia, Syafi'i Ahmad

机构信息

Department of Physics, Institut Teknologi Sepuluh Nopember, Kampus ITS - Sukolilo Surabaya 60111, East Java, Indonesia.

Medical Physicist of Radiotherapy Installation, Naval Hospital Dr. Ramelan, Surabaya 60244, East Java, Indonesia.

出版信息

J Biomed Phys Eng. 2023 Jun 1;13(3):217-226. doi: 10.31661/jbpe.v0i0.2111-1428. eCollection 2023 Jun.

DOI:10.31661/jbpe.v0i0.2111-1428
PMID:37312896
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10258204/
Abstract

BACKGROUND

The patient-specific 3D printed anthropomorphic phantom is used for breast cancer after mastectomy developed by the laboratory of medical physics and biophysics, Department of Physics, Institut Teknologi Sepuluh Nopember, Indonesia. This phantom is applied to simulate and measure the radiation interactions occurring in the human body either using the treatment planning system (TPS) or direct measurement with external beam therapy (EBT) 3 film.

OBJECTIVE

This study aimed to provide dose measurements in the patient-specific 3D printed anthropomorphic phantom using a TPS and direct measurements using single-beam three-dimensional conformal radiation therapy (3DCRT) technique with electron energy of 6 MeV.

MATERIAL AND METHODS

In this experimental study, the patient-specific 3D printed anthropomorphic phantom was used for post-mastectomy radiation therapy. TPS on the phantom was conducted using a 3D-CRT technique with RayPlan 9A software. The single-beam radiation was delivered to the phantom with an angle perpendicular to the breast plane at 337.3° at 6 MeV with a total prescribed dose of 5000 cGy/25 fractions with 200 cGy per fraction.

RESULTS

The doses at planning target volume (PTV) and right lung confirmed a non-significant difference both for TPS and direct measurement with -values of 0.074 and 0.143, respectively. The dose at the spinal cord showed statistically significant differences with a -value of 0.002. The result presented a similar skin dose value using either TPS or direct measurement.

CONCLUSION

The patient-specific 3D printed anthropomorphic phantom for breast cancer after mastectomy on the right side has good potential as an alternative to the evaluation of dosimetry for radiation therapy.

摘要

背景

患者特异性3D打印人体模型由印度尼西亚泗水理工学院物理系医学物理与生物物理实验室开发，用于乳房切除术后的乳腺癌研究。该模型用于模拟和测量人体中发生的辐射相互作用，可通过治疗计划系统（TPS）或使用外照射治疗（EBT）3胶片进行直接测量。

目的

本研究旨在使用TPS并采用电子能量为6 MeV的单束三维适形放射治疗（3DCRT）技术进行直接测量，以获取患者特异性3D打印人体模型中的剂量。

材料与方法

在本实验研究中，患者特异性3D打印人体模型用于乳房切除术后的放射治疗。使用RayPlan 9A软件，采用3D-CRT技术对模型进行TPS分析。以6 MeV的能量，在与乳房平面垂直的角度337.3°向模型提供单束辐射，总处方剂量为5000 cGy/25次分割，每次分割200 cGy。

结果

计划靶区（PTV）和右肺的剂量在TPS和直接测量中均显示无显著差异，-值分别为0.074和0.143。脊髓剂量显示出统计学上的显著差异，-值为0.002。结果表明，使用TPS或直接测量得到的皮肤剂量值相似。

结论

右侧乳房切除术后乳腺癌患者特异性3D打印人体模型作为放射治疗剂量学评估的替代方法具有良好的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78db/10258204/16ba917eef57/JBPE-13-217-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78db/10258204/ab31a5209dd6/JBPE-13-217-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78db/10258204/d97aa68632f1/JBPE-13-217-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78db/10258204/41d87ced1317/JBPE-13-217-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78db/10258204/6f3317b7761c/JBPE-13-217-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78db/10258204/37a65afaeb12/JBPE-13-217-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78db/10258204/16ba917eef57/JBPE-13-217-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78db/10258204/ab31a5209dd6/JBPE-13-217-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78db/10258204/d97aa68632f1/JBPE-13-217-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78db/10258204/41d87ced1317/JBPE-13-217-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78db/10258204/6f3317b7761c/JBPE-13-217-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78db/10258204/37a65afaeb12/JBPE-13-217-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78db/10258204/16ba917eef57/JBPE-13-217-g006.jpg

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