Chassany O, Bergmann J F
Therapeutics Research Unit, Lariboisière Hospital, Paris, France.
Eur J Surg Suppl. 1998(583):81-6. doi: 10.1080/11024159850191300.
Irritable bowel syndrome (IBS) is a common disease in the general population. Evaluation of IBS symptoms does not cover all the complaints of patients who report restrictions to social life, the need to diet and psychosocial repercussions. Quality of life (QOL) measurement permits a precise approach to patient status.
The generic QOL questionnaires SF 36 and two validated specific QOL questionnaires--IBSQOL and Functional Digestive Disorders FDDQL--have been used for the evaluation of IBS patient outcome. IBSQOL measures 9 domains and its reliability and validity have been demonstrated. FDDQL measures 8 domains, an international psychometric validation was obtained in French, English and German by comparison with the SF36. The discriminant validity and responsiveness of the FDDQL have been evaluated.
Generic QOL evaluation and specific questionnaires like the FDDQL were able to measure changes in IBS patient status and QOL during several clinical trials.
Specific QOL questionnaires have been validated in IBS patients and are available for controlled studies. Development of effective new drugs are needed for IBS treatment, complete and precise evaluation of outcome will involve QOL analysis in association with specific validated questionnaires.
肠易激综合征（IBS）是普通人群中的一种常见疾病。对IBS症状的评估并未涵盖那些报告社交生活受限、饮食需求及心理社会影响等所有不适的患者。生活质量（QOL）测量能使我们精确了解患者状况。
通用的QOL问卷SF 36以及两份经验证有效的特定QOL问卷——IBSQOL和功能性消化紊乱FDDQL——已被用于评估IBS患者的治疗结果。IBSQOL测量9个领域，其信度和效度已得到证实。FDDQL测量8个领域，通过与SF36比较，在法语、英语和德语中获得了国际心理测量学验证。已对FDDQL的判别效度和反应度进行了评估。
通用QOL评估以及像FDDQL这样的特定问卷能够在多项临床试验中测量IBS患者状况和QOL的变化。
特定的QOL问卷已在IBS患者中得到验证，可用于对照研究。IBS治疗需要研发有效的新药，对结果进行完整而精确的评估将涉及结合特定验证问卷的QOL分析。
