Badia Xavier, Mearin Fermin, Balboa Agustin, Baró Eva, Caldwell Ellen, Cucala Mercedes, Díaz-Rubio Manuel, Fueyo Arturo, Ponce Julio, Roset Mentse, Talley Nicholas J
Department of Clinical Epidemiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Pharmacoeconomics. 2002;20(11):749-58. doi: 10.2165/00019053-200220110-00004.
To evaluate the burden of illness in irritable bowel syndrome (IBS), in terms of resource utilisation (direct and indirect) and health-related quality of life (HR-QOL), in individuals with IBS who meet Rome I and Rome II criteria.
A cross-sectional study, carried out by personal interview, on a representative sample (n = 2000) of the Spanish population. Individuals with suspected IBS were identified via a screening question and subsequently given an epidemiological questionnaire to complete. The questionnaire collected information on IBS symptoms, resource utilisation, and HR-QOL [Medical Outcomes Study 36-item Short Form (SF-36)].
Sixty-five individuals met Rome II criteria for IBS, while 146 individuals met exclusively Rome I criteria. Of Rome II individuals, 67.7% had consulted some type of healthcare professional in the previous 12 months, compared with only 41.8% of those individuals meeting exclusively Rome I criteria (p vs 17.1%); 'drug consumption' (70.8 vs 45.2%); and 'reduced performance in main activity' (60 vs 27.4%). Compared with the general population, the study sample reported significantly worse HR-QOL scores in four dimensions of the SF-36 ('bodily pain', 'vitality', 'social functioning' and 'role-emotional'. Additionally, individuals meeting Rome II criteria reported worse HR-QOL scores than those individuals meeting exclusively Rome I criteria, especially in the 'bodily pain' and 'general health' dimensions.
The burden of illness in IBS is important and correlated to the diagnostic criteria employed. Individuals who met Rome II criteria reported a higher level of resource utilisation and worse HR-QOL than individuals meeting exclusively Rome I criteria.
评估符合罗马I和罗马II标准的肠易激综合征（IBS）患者在资源利用（直接和间接）及健康相关生活质量（HR-QOL）方面的疾病负担。
通过个人访谈对西班牙人口的代表性样本（n = 2000）进行横断面研究。通过筛查问题识别疑似IBS的个体，随后给予其一份流行病学调查问卷以完成。该问卷收集了有关IBS症状、资源利用和HR-QOL[医学结局研究36项简短量表（SF-36）]的信息。
65名个体符合IBS的罗马II标准，而146名个体仅符合罗马I标准。在罗马II标准的个体中，67.7%在过去12个月内咨询过某种医疗保健专业人员，而仅符合罗马I标准的个体这一比例为41.8%（p vs 17.1%）；“药物消费”（70.8对45.2%）；以及“主要活动表现下降”（60对27.4%）。与一般人群相比，研究样本在SF-36的四个维度（“身体疼痛”、“活力”、“社会功能”和“角色-情感”）上的HR-QOL得分显著更差。此外，符合罗马II标准的个体报告的HR-QOL得分比仅符合罗马I标准的个体更差，尤其是在“身体疼痛”和“总体健康”维度。
IBS的疾病负担较重，且与所采用的诊断标准相关。符合罗马II标准的个体比仅符合罗马I标准的个体报告的资源利用水平更高，HR-QOL更差。
