Hulshoff A, Perrin J H
J Chromatogr. 1976 Dec 22;129:263-76. doi: 10.1016/s0021-9673(00)87784-5.
Relative partition coefficients (P) of 1,4-benzodiazepines were determined by a reversed-phase thin-layer chromatographic (RP-TLC) technique in the systemoleyl alcohol-water, and by high-performance liquid chromatography (HPLC) using several column packing materials. RMw values, obtained by RP-TLC, correlated well with log P values determined directly in the system oleyl alcohol-water and with the literature values for the system 1-octanol-water. Th log k' w values from the HPLC experiments could be determined with greater precision, but the correlations of log k'w with log Poleyl alcohol and log Poctanol were not as good as those found for the Rmw values.
采用反相薄层色谱（RP-TLC）技术在油醇-水体系中，以及使用几种柱填充材料通过高效液相色谱（HPLC）测定了1,4-苯二氮䓬类药物的相对分配系数（P）。通过RP-TLC获得的RMW值与直接在油醇-水体系中测定的log P值以及1-辛醇-水体系的文献值具有良好的相关性。HPLC实验得到的log k'w值可以更精确地测定，但log k'w与油醇log P以及辛醇log P的相关性不如RMW值的相关性好。
