Sainz Y, Montoya M E, Martínez-Crespo F J, Ortega M A, López de Ceráin A, Monge A
Centro de Investigación en Farmacobiología Aplicada, Universidad de Navarra, Pamplona, Spain.
Arzneimittelforschung. 1999 Jan;49(1):55-9. doi: 10.1055/s-0031-1300359.
Some quinoxaline 1,4-di-N-oxides derivatives with very different substituents in 2, 3, 6 and 7 positions have been synthesized in order to obtain new hypoxia selective agents. Some of these products have been tested as antituberculosis agents and very interesting results have been obtained from the first screening.
为了获得新的低氧选择性药物，已合成了一些在2、3、6和7位具有非常不同取代基的喹喔啉1,4 - 二 - N - 氧化物衍生物。其中一些产品已作为抗结核药物进行了测试，并且首次筛选已获得了非常有趣的结果。
