Unidad de Investigación y Desarrollo de Medicamentos, Centro de Investigación en Farmacobiología Aplicada (CIFA), University of Navarra, C/Irunlarrea s/n, 31008 Pamplona, Spain.
Bioorg Med Chem. 2010 Apr 1;18(7):2713-9. doi: 10.1016/j.bmc.2010.02.024. Epub 2010 Feb 20.
Mycobacterium tuberculosis (M.Tb) is a bacillus capable of causing a chronic and fatal condition in humans known as tuberculosis (TB). It is estimated that there are 8 million new cases of TB per year and 3.1 million infected people die annually. Thirty-six new amide quinoxaline 1,4-di-N-oxide derivatives have been synthesized and evaluated as potential anti-tubercular agents, obtaining biological values similar to the reference compound, Rifampin (RIF).
结核分枝杆菌（M.Tb）是一种杆菌，能够在人类中引起慢性和致命的疾病，称为结核病（TB）。据估计，每年有 800 万例新的结核病病例，每年有 310 万人感染结核病。已经合成了 36 种新的酰胺喹喔啉 1,4-二 N-氧化物衍生物，并作为潜在的抗结核药物进行了评估，获得了与参比化合物利福平（RIF）相似的生物学值。
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