el Gammal S, Pieck C, Auer T, Kaspar K, Hoffmann K, Altmeyer P, Vogt M, Ermert H
Dermatologische Klinik, Ruhr-Universität Bochum.
Ultraschall Med. 1998 Dec;19(6):270-4. doi: 10.1055/s-2007-1000503.
20 MHz sonography of inflammatory diseases has concentrated on the evaluation of the echo-poor area in the upper dermis. With regard to higher resolution, this study focuses on the alterations of the epidermis and upper dermis skin using 100 MHz sonography.
70 fully developed psoriasis vulgaris plaques of 20 patients were examined using our 100 MHz ultrasound equipment after application of salicylic acid in petrolatum for 24 h. After informing the patient about the aims of the study, a small knife biopsy was taken from 11 plaques.
All psoriasis plaques exhibited, in comparison with normal skin, a significant widening of the skin entry echo (p < 0.001). Focally, this echo-rich line broke up into two thinner lines. Correlating histology exhibited in these areas an orthohyperkeratosis and focal parakeratosis. The upper dermis showed an echo-poor, band-shaped area which corresponded histologically to an acanthosis, elongation of rete ridges, and widening of the stratum papillare. The mean grey level of the echo-poor area and of the dermis beneath was significantly lower (p < 0.001) than the normal adjacent dermis. The thickness of the echo-poor area correlated with the thickness of the sum of the acanthosis and the inflammatory infiltrate in the histological sections (r = 0.94).
Using 100 MHz sonography changes of the skin entry echo and the upper dermis can be visualized and quantified.
20兆赫超声对炎症性疾病的研究主要集中在上层真皮回声减低区域的评估。鉴于更高的分辨率，本研究聚焦于使用100兆赫超声观察表皮和上层真皮的变化。
20例患者的70块完全发展的寻常型银屑病斑块，在涂抹水杨酸凡士林24小时后，使用我们的100兆赫超声设备进行检查。在告知患者研究目的后，从11块斑块处取小块组织进行活检。
与正常皮肤相比，所有银屑病斑块均表现出皮肤入射回声显著增宽（p < 0.001）。局部地，这条高回声线分裂成两条较细的线。这些区域的相关组织学表现为正角化过度和局灶性角化不全。上层真皮显示出一个回声减低的带状区域，组织学上对应棘层增厚、 rete嵴延长和乳头层增宽。回声减低区域及其下方真皮的平均灰度显著低于相邻正常真皮（p < 0.001）。回声减低区域的厚度与组织学切片中棘层增厚和炎症浸润的总厚度相关（r = 0.94）。
使用100兆赫超声可以观察并量化皮肤入射回声和上层真皮的变化。
