Turanli G, Yalnizoğlu D, Renda Y
Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara.
Turk J Pediatr. 1998 Oct-Dec;40(4):473-80.
Intractable epilepsies and partial epilepsies, which make up a great majority of epileptic disorders, are not better recognized and their etiologies unveiled with the help of the new imaging techniques. The development of magnetic resonance imaging (MRI) permits the accurate diagnosis while the patients are alive of the neuronal migration disorders (NMD), which constitute an important group of intractable epilepsies. Previously, NMD cases were described by neuropathologists from autopsy materials, and many of these developmental disorders were not considered compatible with prolonged survival. Cerebral malformations due to neuronal migration anomalies are described in association with motor and mental retardation, learning disabilities, microcephaly, dysmorphic features and epilepsy. Neuronal migration takes place in all parts of the central nervous system (CNS) during the shaping process of the CNS; it actually includes both the central and peripheral nervous systems. However, in common usage the meaning of "neuronal migration disorders" is restricted to the neocortex.
难治性癫痫和部分性癫痫占癫痫疾病的绝大部分，借助新的成像技术，它们并未得到更好的认识，其病因也未被揭示。磁共振成像（MRI）的发展使得在患者存活时能够准确诊断构成难治性癫痫重要组别的神经元迁移障碍（NMD）。此前，神经病理学家根据尸检材料描述NMD病例，许多这些发育障碍被认为与长期存活不相容。因神经元迁移异常导致的脑畸形与运动和智力发育迟缓、学习障碍、小头畸形、畸形特征和癫痫相关。在中枢神经系统（CNS）的塑形过程中，神经元迁移发生在中枢神经系统的所有部位；实际上它包括中枢神经系统和周围神经系统。然而，在通常用法中，“神经元迁移障碍”的含义仅限于新皮层。
