Soucy D M, Rudé M, Hsia W C, Hagedorn F N, Illner H, Shires G T
Department of Surgery, Texas Tech University Health Sciences Center, Lubbock 79430, USA.
J Trauma. 1999 Feb;46(2):209-15. doi: 10.1097/00005373-199902000-00001.
The role of rate and volume of infusion in survival from experimental uncontrolled hemorrhage was evaluated.
Hemorrhage was initiated using tail resection in 43 female rats assigned to the following five groups: nonresuscitated; resuscitated with moderate volume, slower rate; resuscitated with moderate volume, faster rate; resuscitated with high volume, slower rate; and resuscitated with high volume, faster rate.
A trend toward improved survival was noted with faster rate of infusion (60 vs. 33.3% survival rate with moderate volume and 28.6 vs. 12.5% with high volume, compared with 16.7% in the nonresuscitated animals).
Rapid infusion of moderate volume of isotonic saline improved survival in uncontrolled hemorrhage. Extreme volumes, infused rapidly, also resulted in higher survival rates compared with those observed in nonresuscitated rats.
评估了输注速率和容量对实验性非控制性出血存活率的作用。
对43只雌性大鼠进行尾切除以引发出血，将其分为以下五组：未复苏组；中等容量、较慢速率复苏组；中等容量、较快速率复苏组；大容量、较慢速率复苏组；大容量、较快速率复苏组。
观察到输注速率较快时存活率有改善趋势（中等容量时，复苏组存活率为60%，未复苏组为33.3%；大容量时，复苏组存活率为28.6%，未复苏组为12.5%）。
快速输注中等容量的等渗盐水可提高非控制性出血的存活率。与未复苏大鼠相比，快速输注极大量液体也可使存活率更高。
