Masamoto T, Ohashi Y, Nakai Y
Department of Otolaryngology, Osaka City University Medical School, Japan.
Ann Otol Rhinol Laryngol. 1999 Feb;108(2):169-76. doi: 10.1177/000348949910800212.
This study included 23 nonatopic volunteers and 84 patients with seasonal allergic rhinitis due to Japanese cedar pollen. Serum interleukin-4 (IL-4) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in the patients were significantly higher than those in the nonatopic individuals, even outside of the pollen season. Both the good responders and the poor responders to antihistamine tablets showed significant increases in IL-4 and specific IgE during the pollen season, whereas such seasonal increases were not observed in the good responders to immunotherapy. Seasonal increases in IL-4 were significantly correlated with those of specific IgE. However, seasonal increases in sVCAM-1 were not significant. Seasonal increases in sVCAM-1 were not significantly different between the good responders and the poor responders to pharmacotherapy or immunotherapy. In conclusion, serum IL-4 and sVCAM-1 are increased in patients with seasonal allergic rhinitis, even outside of the pollen season; this finding might suggest underlying preponderant in vivo activation of T helper cell-2-like cells and inflammatory events in seasonal allergic rhinitis. A seasonal increase in IL-4 in sera might be at least partly involved in the seasonal increase in specific IgE in sera. Immunotherapy's inhibitory effect on IL-4 production and specific IgE response might be one of its working mechanisms.
本研究纳入了23名非特应性志愿者和84名因日本雪松花粉导致季节性变应性鼻炎的患者。即使在花粉季节之外，患者血清中的白细胞介素-4（IL-4）和可溶性血管细胞黏附分子-1（sVCAM-1）也显著高于非特应性个体。抗组胺药片治疗的有效应答者和无效应答者在花粉季节期间IL-4和特异性IgE均显著升高，而免疫疗法的有效应答者未观察到此类季节性升高。IL-4的季节性升高与特异性IgE的季节性升高显著相关。然而，sVCAM-1的季节性升高并不显著。药物治疗或免疫治疗的有效应答者和无效应答者之间，sVCAM-1的季节性升高无显著差异。总之，季节性变应性鼻炎患者血清中的IL-4和sVCAM-1升高，即使在花粉季节之外也是如此；这一发现可能提示季节性变应性鼻炎中T辅助细胞2样细胞的体内潜在优势激活和炎症事件。血清中IL-4的季节性升高可能至少部分参与了血清中特异性IgE的季节性升高。免疫疗法对IL-4产生和特异性IgE反应的抑制作用可能是其作用机制之一。
