Li Zhi-Peng, Yin Li-Li, Wang Hui, Liu Li-Si
Department of Otorhinolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
J Huazhong Univ Sci Technolog Med Sci. 2014 Jun;34(3):306-313. doi: 10.1007/s11596-014-1275-3. Epub 2014 Jun 18.
The relationship of interleukin-4 (IL-4) C-33T and C-590T (C-589T) gene polymorphisms with allergic rhinitis was analyzed. Data about the case control studies of IL-4 gene promoter polymorphisms [C-33T and C-590T (C-589T)] and their association with allergic diseases and correlation between serum IL-4 levels and allergic rhinitis were retrieved. The Stata 12.0 statistical software was applied to analyze the correlation between IL-4 gene polymorphisms and allergic rhinitis. The meta-analysis result of TT/CC genotype of -590 (-589) polymorphism showed a significant association with allergic diseases [OR=1.93, 95% CI (1.61-2.31), P=0.00]. Meta-analysis of the TT+TC versus CC genotype of IL-4 C-33/T polymorphism revealed significant associations with allergic diseases [OR=3.23, 95% CI (1.13-9.25), P=0.03]. Meanwhile, there was a significant correlation between serum IL-4 levels and allergic rhinitis [OR=2.52, 95% CI=(1.80-3.23), P=0.00]. IL-4 gene -590 TT genotype may increase the risk of allergic rhinitis and the T allele mutation of -33 might be correlated with allergic rhinitis.
分析白细胞介素-4（IL-4）C-33T和C-590T（C-589T）基因多态性与变应性鼻炎的关系。检索关于IL-4基因启动子多态性[C-33T和C-590T（C-589T）]的病例对照研究数据及其与变应性疾病的关联以及血清IL-4水平与变应性鼻炎之间的相关性。应用Stata 12.0统计软件分析IL-4基因多态性与变应性鼻炎之间的相关性。-590（-589）多态性的TT/CC基因型的Meta分析结果显示与变应性疾病有显著关联[比值比（OR）=1.93，95%可信区间（CI）（1.61 - 2.31），P = 0.00]。IL-4 C-33/T多态性的TT + TC与CC基因型的Meta分析显示与变应性疾病有显著关联[OR = 3.23，95% CI（1.13 - 9.25），P = 0.03]。同时，血清IL-4水平与变应性鼻炎之间存在显著相关性[OR = 2.52，95% CI =（1.80 - 3.23），P = 0.00]。IL-4基因-590 TT基因型可能增加变应性鼻炎的风险，-33的T等位基因突变可能与变应性鼻炎相关。
