Su M Y, Wang Z, Nalcioglu O
Health Sciences Research Imaging Center, College of Medicine, University of California, Irvine 92697-5020, USA.
J Magn Reson Imaging. 1999 Jan;9(1):128-37. doi: 10.1002/(sici)1522-2586(199901)9:1<128::aid-jmri17>3.0.co;2-e.
The impact of chemotherapy on longitudinal vascular changes taking place during the growth of an animal tumor, R3230 AC adenocarcinoma, was investigated. Two contrast agents of different molecular weights, gadolinium-diethylene-triamine-pentaacetic acid (Gd-DTPA; < 1 kD) and gadomer-17 (35 kD), were used in the dynamic imaging studies. Enhancement kinetics were analyzed by a pharmacokinetic model to derive parameters related to vascular volume and permeability on a pixel-by-pixel basis. Responders and non-responders were separated according to tumor size 10 days after the therapy. Changes in the vascular volume measured by gadomer-17 at 4 days after therapy revealed a clear distinction between the controls and the responders/non-responders. Mean vascular volume decreased by 42% in responders but was not significantly changed in the controls. The one non-responder had increased vascular volume after chemotherapy. Enhancement kinetics of gadomer-17 detected the changes earlier and with greater sensitivity than Gd-DTPA. In the control group, vascular permeability determined by gadomer-17 correlated with the longitudinal growth rates of tumors, suggesting that vascular permeability assessed by gadomer-17 could potentially serve as an indicator of aggressive tumor growth.
研究了化疗对动物肿瘤R3230 AC腺癌生长过程中纵向血管变化的影响。在动态成像研究中使用了两种不同分子量的造影剂，钆-二乙烯三胺五乙酸（Gd-DTPA；<1 kD）和钆聚合物-17（35 kD）。通过药代动力学模型分析增强动力学，以逐像素得出与血管体积和通透性相关的参数。根据治疗后10天的肿瘤大小将反应者和无反应者分开。治疗后4天用钆聚合物-17测量的血管体积变化显示，对照组与反应者/无反应者之间有明显区别。反应者的平均血管体积减少了42%，但对照组无明显变化。一名无反应者化疗后血管体积增加。钆聚合物-17的增强动力学比Gd-DTPA更早且更灵敏地检测到这些变化。在对照组中，钆聚合物-17测定的血管通透性与肿瘤的纵向生长速率相关，这表明钆聚合物-17评估的血管通透性可能作为侵袭性肿瘤生长的一个指标。
