Su M Y, Mühler A, Lao X, Nalcioglu O
Department of Radiological Sciences, University of California, Irvine 92697-5020, USA.
Magn Reson Med. 1998 Feb;39(2):259-69. doi: 10.1002/mrm.1910390213.
Dynamic contrast-enhanced MR imaging was used to measure the kinetics of enhancement in three different animal tumor models (Walker 256, R3230 AC, MCF7) using three different Gd complexes (Gd-DTPA, Gd-DTPA-24-cascade-polymer 30 kD, and polylysine-Gd-DTPA 50 kD). The three tumor models varied in growth rate, with the most rapid growth demonstrated by Walker 256 cells and the slowest growth occurring in the MCF7 cells. For each tumor, the kinetics of enhancement using polylysine-Gd-DTPA was analyzed using a pharmacokinetic model to estimate the vascular volume of the tumor. The rate of entry of the contrast agent into the interstitial space served as the measure of vascular permeability. The smallest molecular-weight agent, Gd-DTPA, could not provide information about vascular permeability. The intermediate and the largest agents both demonstrated that the faster-growing Walker 256 tumor had greater vascular permeability than did the slower-growing R3230 AC tumor. The degree of vascular permeability in the MCF7 tumor could not be assessed fairly due to insufficient statistics. The current study provides evidence supporting the hypothesis that more rapidly growing tumors have higher vascular permeability than do tumors that grow more slowly.
动态对比增强磁共振成像用于测量三种不同动物肿瘤模型（Walker 256、R3230 AC、MCF7）使用三种不同钆配合物（钆-二乙三胺五乙酸、钆-二乙三胺五乙酸-24-级联聚合物30 kD和聚赖氨酸-钆-二乙三胺五乙酸50 kD）时的增强动力学。这三种肿瘤模型生长速率各不相同，其中Walker 256细胞生长最快，MCF7细胞生长最慢。对于每种肿瘤，使用药代动力学模型分析聚赖氨酸-钆-二乙三胺五乙酸的增强动力学，以估计肿瘤的血管容积。造影剂进入间质间隙的速率用作血管通透性的指标。分子量最小的试剂钆-二乙三胺五乙酸无法提供有关血管通透性的信息。中间和最大的试剂均表明，生长较快的Walker 256肿瘤比生长较慢的R3230 AC肿瘤具有更高的血管通透性。由于统计数据不足，无法对MCF7肿瘤的血管通透性程度进行公平评估。当前研究提供了证据支持这一假设，即生长较快的肿瘤比生长较慢的肿瘤具有更高的血管通透性。
