柴芍承气汤对黑泽和草柳高胆固醇血症兔动脉粥样硬化病变进展的抑制作用。

Inhibitory effects of Dai-saiko-to (Da-Chai-Hu-Tang) on the progression of atherosclerotic lesions in Kurosawa and Kusanagi-hypercholesterolemic rabbits.

作者信息

Iizuka A, Iijima O T, Yoshie F, Makino B, Amagaya S, Komatsu Y, Kondo K, Matsumoto A, Itakura H

机构信息

Kampo and Pharmacognosy Laboratory, Central Research Laboratories, Tsumura and Co., Ibaraki, Japan.

出版信息

J Ethnopharmacol. 1998 Dec;63(3):209-18. doi: 10.1016/s0378-8741(98)00083-x.

DOI:10.1016/s0378-8741(98)00083-x

PMID:10030725

Abstract

The inhibitory effects of the traditional herbal medicine Dai-saiko-to (Da-Chai-Hu-Tang) on the progression of the atherosclerotic lesions were studied using the spontaneous familial hypercholesterolemia (FH) model, Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits. Changes in blood chemistry, pathology and low-density lipoprotein (LDL) oxidation were measured in a control group and a Dai-saiko-to-treated group. In the control group, the area of atheromatous plaques of the aorta progressed between week 12 (29.1%) and 26 (51.5%). This progression of atherosclerotic lesions did not happen in the Dai-saiko-to-treated group between week 12 (26%) and 26 (27.4%). Antioxidative effects on LDL were seen in the Dai-saiko-to-treated group in weeks 16 and 18. Dai-saiko-to did not improve the hypercholesterolemia in the KHC rabbits. These results suggest that Dai-saiko-to has inhibitory effects on the development of atheromatous plaque formation in spontaneous FH model rabbits. It is possible that the antioxidative effects of Dai-saiko-to on LDL led to the beneficial effects observed in this study.

摘要

利用自发性家族性高胆固醇血症（FH）模型——黑泽和草柳高胆固醇血症（KHC）兔，研究了传统草药大柴胡汤对动脉粥样硬化病变进展的抑制作用。在对照组和大柴胡汤治疗组中，检测了血液生化、病理学及低密度脂蛋白（LDL）氧化的变化。在对照组中，主动脉粥样斑块面积在第12周（29.1%）至第26周（51.5%）期间有所进展。在大柴胡汤治疗组中，第12周（26%）至第26周（27.4%）期间未出现动脉粥样硬化病变的这种进展。在第16周和第18周时，大柴胡汤治疗组出现了对LDL的抗氧化作用。大柴胡汤并未改善KHC兔的高胆固醇血症。这些结果表明，大柴胡汤对自发性FH模型兔动脉粥样斑块形成的发展具有抑制作用。大柴胡汤对LDL的抗氧化作用可能导致了本研究中观察到的有益效果。