Spencer G S, Zorab P A
J Neurol Sci. 1976 Dec;30(2-3):405-10. doi: 10.1016/0022-510x(76)90143-x.
Spinal muscle biopsies from 7 rabbits with experimentally-produced scoliosis and from 4 normal control rabbits, were examined histologically and histochemically. One scoliotic rabbit showed selective Type 2 fibre atrophy in its muscles, but in general there was no difference between the normal and the scoliotic rabbits. The percentage area of muscle occupied by Type 1 and Type 2 fibres was determined using a computer controlled microscope. There was no asymmetry in the muscles of either the normal or the scoliotic rabbits on the two sides of the spine. These results suggest that the abnormalities and asymmetry of fibre type proportions reported in human scoliotic muscles are not a consequence of the scoliosis. Within the limits of the study, it is suggested that the abnormalities reported in the muscles of human scoliotic patients are at least an important factor in the causation of "idiopathic" scoliosis.
对7只实验性脊柱侧弯兔和4只正常对照兔的脊柱肌肉活检标本进行了组织学和组织化学检查。一只脊柱侧弯兔的肌肉出现了选择性Ⅱ型纤维萎缩，但总体而言，正常兔和脊柱侧弯兔之间没有差异。使用计算机控制显微镜测定Ⅰ型和Ⅱ型纤维所占肌肉面积的百分比。正常兔和脊柱侧弯兔脊柱两侧的肌肉均无不对称现象。这些结果表明，人类脊柱侧弯肌肉中所报道的纤维类型比例异常和不对称并非脊柱侧弯的结果。在本研究范围内，提示人类脊柱侧弯患者肌肉中所报道的异常至少是“特发性”脊柱侧弯病因中的一个重要因素。
