Poole C A, Rowe M I
J Pediatr Surg. 1976 Dec;11(6):1011-22. doi: 10.1016/s0022-3468(76)80083-8.
The use of barium sulfate as the contrast agent of choice in the radiographic evaluation of distal neonatal intestinal obstruction is advocated. The advantages of Gastrografin or other water-soluble contrast materials are far outweighed by their disadvantages, which include the hazards of hypertonic dehydration and the danger of missing the diagnosis of Hirschsprung's disease. Five patients are presented, all of whom had the diagnosis of Hirschsprung's disease missed in the neonatal period with one use of Gastrografin enemas. All five were subsequently admitted to the Surgical Neonatal Intensive Care Unit, critically ill with enterocolitis of Hirschsprung's disease.
提倡在新生儿远端肠梗阻的放射学评估中使用硫酸钡作为首选造影剂。泛影葡胺或其他水溶性造影剂的缺点远远超过其优点，这些缺点包括高渗性脱水的风险以及漏诊先天性巨结肠的危险。本文介绍了5例患者，他们在新生儿期均因使用一次泛影葡胺灌肠而漏诊先天性巨结肠。所有5例随后均被收入外科新生儿重症监护病房，因先天性巨结肠合并小肠结肠炎而病情危重。
