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Use of cluster analysis in the development of structure-activity relations for antitumor triazenes.

作者信息

Dunn W J, Greenberg M J, Callejas S S

出版信息

J Med Chem. 1976 Nov;19(11):1299-301. doi: 10.1021/jm00233a009.

DOI:10.1021/jm00233a009
PMID:1003406
Abstract

A series of antitumor triazenes in which the members of the series are physicochemically distinct was designed using the cluster analysis approach as proposed by Hansch and his co-workers. The series that resulted was tested against Sarcoma 180 in the mouse and the antitumor activities were analyzed using regression techniques. The structure-activity relations that resulted are discussed in terms of proposed mechanisms of action.

摘要

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