抗肿瘤1-（X-芳基）-3,3-二烷基三氮烯。1. 与小鼠L1210白血病相关的定量构效关系
Antitumor 1-(X-aryl)-3,3-dialkyltriazenes. 1. Quantitative structure-activity relationships vs. L1210 leukemia in mice.
作者信息
Hatheway G J, Hansch C, Kim K H, Milstein S R, Schmidt C L, Smith R N, Quinn F R
出版信息
J Med Chem. 1978 Jun;21(6):563-74. doi: 10.1021/jm00204a012.
PMID:671453
Abstract
Quantitative structure-activity relationships (QSAR) have been formulated for phenyl-, pyrazolyl-, and imidazolyltriazenes acting L1210 leukemia in mice. All three sets of congeners have the same ideal lipophilicity (log Po approximately 1). Electron releasing substituents increase potency; ortho substitution decreases activity. The synthesis of a number of new triazenes and some of their partition coefficients are reported.
摘要
已经针对作用于小鼠L1210白血病的苯基三氮烯、吡唑基三氮烯和咪唑基三氮烯建立了定量构效关系（QSAR）。所有三组同系物都具有相同的理想亲脂性（log Po约为1）。供电子取代基会增加效力；邻位取代会降低活性。报道了一些新三氮烯的合成及其一些分配系数。
Zotero 插件