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Synthesis and antitumor activity of 4'-deoxydaunorubicin and 4'-deoxyadriamycin.

作者信息

Arcamone F, Penco S, Redaelli S, Hanessian S

出版信息

J Med Chem. 1976 Dec;19(12):1424-5. doi: 10.1021/jm00234a016.

DOI:10.1021/jm00234a016
PMID:1003430
Abstract
摘要

相似文献

1
Synthesis and antitumor activity of 4'-deoxydaunorubicin and 4'-deoxyadriamycin.4'-去氧柔红霉素和4'-去氧阿霉素的合成及其抗肿瘤活性
J Med Chem. 1976 Dec;19(12):1424-5. doi: 10.1021/jm00234a016.
2
Synthesis and antileukemic activity of N-enamine derivatives of daunorubicin, 5-iminodaunorubicin, and doxorubicin.柔红霉素、5-亚氨基柔红霉素和阿霉素的N-烯胺衍生物的合成及其抗白血病活性
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Synthesis of antitumor-active 7-O-(2,6-dideoxy-2-fluoro-alpha-L-talopyranosyl)-daunomycinone and -adriamycinone.抗肿瘤活性的7 - O -(2,6 - 二脱氧 - 2 - 氟 -α - L - 塔罗吡喃糖基)柔红霉素酮和阿霉素酮的合成。
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Synthesis and antitumor activity of 7-O-[2,6-dideoxy-2-fluoro-5-C-(trifluoromethyl)-alpha-L-talopyranosyl]- daunomycinone and -adriamycinone.7-O-[2,6-二脱氧-2-氟-5-C-(三氟甲基)-α-L-塔罗吡喃糖基]-柔红霉素酮和-阿霉素酮的合成及其抗肿瘤活性
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Stereocontrolled glycosidation of daunomycinone. Synthesis and biological evaluation of 6-hydroxy-L-arabino analogues of antitumor anthracyclines.柔红霉素酮的立体控制糖基化。抗肿瘤蒽环类药物6-羟基-L-阿拉伯糖类似物的合成及生物学评价。
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J Antibiot (Tokyo). 1989 Aug;42(8):1318-20. doi: 10.7164/antibiotics.42.1318.

引用本文的文献

1
Fluorescence assays and pharmacokinetic studies of 4'-deoxydoxorubicin and doxorubicin in organs of mice bearing solid tumors.4'-脱氧阿霉素和阿霉素在荷实体瘤小鼠器官中的荧光测定及药代动力学研究。
Cancer Chemother Pharmacol. 1981;5(3):139-44. doi: 10.1007/BF00258470.
2
Synthesis, biological and biochemical properties of new anthracyclines modified in the aminosugar moiety.氨基糖部分修饰的新型蒽环类药物的合成、生物学及生物化学性质
Cancer Chemother Pharmacol. 1983;10(2):84-9. doi: 10.1007/BF00446215.
3
Phase I trial with 4'-deoxydoxorubicin (esorubicin).
4'-脱氧阿霉素(表柔比星)的I期试验。
Invest New Drugs. 1983;1(4):309-13. doi: 10.1007/BF00177414.
4
Phase I trial of 4'-deoxydoxorubicin given weekly.每周给予4'-脱氧阿霉素的I期试验。
Invest New Drugs. 1984;2(4):369-73. doi: 10.1007/BF00171587.
5
Phase I study with 4'-deoxydoxorubicin.4'-脱氧阿霉素的I期研究。
Invest New Drugs. 1984;2(3):287-95. doi: 10.1007/BF00175379.
6
Cytotoxic effect of dose and schedule on normal murine hematopoietic progenitor cells following the administration of 4'-deoxydoxorubicin.给予4'-脱氧阿霉素后剂量和给药方案对正常小鼠造血祖细胞的细胞毒性作用
Br J Cancer. 1984 Nov;50(5):647-56. doi: 10.1038/bjc.1984.231.
7
High incidence of local venous reactions to esorubicin.表柔比星局部静脉反应的高发生率。
Invest New Drugs. 1987;5(1):31-5. doi: 10.1007/BF00217666.
8
Anthracycline analogs: the past, present, and future.蒽环类类似物:过去、现在与未来。
Cancer Chemother Pharmacol. 1986;18(3):185-97. doi: 10.1007/BF00273384.
9
Phase II study of esorubicin (4'-deoxydoxorubicin) in advanced or metastatic squamous carcinoma of the uterine cervix: a Gynecologic Oncology Group Study.
Invest New Drugs. 1989 Jul;7(2-3):235-8. doi: 10.1007/BF00170865.
10
Phase I study of 4'-deoxydoxorubicin (esorubicin) in children with malignant solid tumors.
Invest New Drugs. 1989 Jul;7(2-3):209-11. doi: 10.1007/BF00170859.