3'-C-甲基柔红霉素的合成及其抗肿瘤活性
Synthesis and antitumor activity of 3'-C-methyl-daunorubicin.
作者信息
Thang T T, Imbach J L, Fizames C, Lavelle F, Ponsinet G, Olesker A, Lukacs G
出版信息
Carbohydr Res. 1985 Jan 15;135(2):241-7. doi: 10.1016/s0008-6215(00)90775-4.
PMID:3986844
Abstract
Reaction of 1,5-anhydro-4-O-benzoyl-2,3,6-trideoxy-3-C-methyl-3-trifluoro-acetami no-L-lyxo-hex-1-enitol with daunomycinone in the presence of anhydrous toluene-p-sulfonic acid in benzene, followed by removal of the N- and O-protecting groups under mild conditions, gave 3'-C-methyldaunorubicin. The antitumor activity of the new anthracycline glycoside has been evaluated.
摘要
1,5-脱水-4-O-苯甲酰基-2,3,6-三脱氧-3-C-甲基-3-三氟乙酰氨基-L-来苏-己-1-烯醇与柔红霉素酮在苯中无水对甲苯磺酸存在下反应，然后在温和条件下去除N-和O-保护基，得到3'-C-甲基柔红霉素。已评估了这种新的蒽环类糖苷的抗肿瘤活性。
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