Playfer J R, Eze L C, Bullen M F, Evans D A
J Med Genet. 1976 Oct;13(5):337-42. doi: 10.1136/jmg.13.5.337.
A method for determining plasma paroxonase activity using an auto-analyser is described. Frequency distributions for British and Indian subjects show bimodality. A study of 40 British families confirms the presence of a genetic polymorphism with regard to plasma paroxonase activity. Two phenotypes can be defined, controlled by two alleles at one autosomal locus. The frequency of the low activity phenotype is less in the Indian population than in the British population. Malay, Chinese, and African subjects fail to show obvious bimodality.
描述了一种使用自动分析仪测定血浆对氧磷酶活性的方法。英国人和印度人的频率分布显示为双峰性。对40个英国家庭的研究证实了血浆对氧磷酶活性存在基因多态性。可以定义两种表型，由一个常染色体位点上的两个等位基因控制。低活性表型的频率在印度人群中低于英国人群。马来人、中国人和非洲人未表现出明显的双峰性。
