Nagel D L, Stenbäck F, Clayson D B, Wallcave L
J Natl Cancer Inst. 1976 Jul;57(1):119-23. doi: 10.1093/jnci/57.1.119.
The morphologic effects and the retention and distribution times of single and multiple intratracheal instillations in Syrian hamsters of 7H-dibenzo[c,g]carbazole (DBC) and benzo[a]pyrene (BP) were compared. A single instillation of DBC induced slight changes in the hamster respiratory tract; however, five treatments caused tracheobronchial epithelial proliferation, cell hyperplasia, and occasionally, squamous metaplasia. The particle size of both carcinogens was approximately the same. BP in saline remained longer in the lungs than did DBC in saline. The shortest retention time was recorded when DBC was administered in aqueous solution, whereas multiple doses of DBC in aqueous solution did not markedly affect retention time. DBC passed from the lungs to the intestinal tract and was mainly excreted in the feces.
比较了7H - 二苯并[c,g]咔唑（DBC）和苯并[a]芘（BP）单次和多次气管内滴注对叙利亚仓鼠的形态学影响以及留存和分布时间。单次滴注DBC会引起仓鼠呼吸道的轻微变化；然而，五次处理会导致气管支气管上皮细胞增殖、细胞增生，偶尔还会出现鳞状化生。两种致癌物的颗粒大小大致相同。盐水中的BP在肺部留存的时间比盐水中的DBC长。当DBC以水溶液形式给药时，记录到最短的留存时间，而水溶液中多次给药的DBC对留存时间没有明显影响。DBC从肺部转移到肠道，主要通过粪便排出。
