Sellakumar A, Stenbäck F, Rowland J, Shubik P
J Toxicol Environ Health. 1977 Dec;3(5-6):935-9. doi: 10.1080/15287397709529627.
The respiratory tract of male and female Syrian golden hamsters was treated intratracheally with 7H-dibenzo[c,g]carbazole (DBC), a tobacco smoke component. The carcinogen was given by multiple instillations at two dose levels. At the lower dose (9 mg), 35 of 46 hamsters (72%) developed respiratory tract tumors. The group receiving treatment at the higher dose level (30 mg) died earlier because of the toxicity of the compound. In this group, 15 of 45 animals (33%) had respiratory tract tumors. These occurred in the larynx, trachea, bronchi, and lungs, but predominated in the trachea and bronchi. Morphologically, most tumors were papillomas and squamous cell carcinomas. This study indicates the highly potent carcinogenic effect of DBC and that respiratory tumors can be induced in this model system without any carrier dust.
将烟草烟雾成分7H-二苯并[c,g]咔唑（DBC）经气管内注入雄性和雌性叙利亚金黄地鼠的呼吸道。致癌物以两种剂量水平多次滴注给药。在较低剂量（9毫克）时，46只仓鼠中有35只（72%）发生了呼吸道肿瘤。接受较高剂量水平（30毫克）治疗的组因该化合物的毒性而较早死亡。在该组中，45只动物中有15只（33%）患有呼吸道肿瘤。这些肿瘤发生在喉、气管、支气管和肺，但以气管和支气管为主。形态学上，大多数肿瘤为乳头状瘤和鳞状细胞癌。本研究表明DBC具有高度致癌作用，并且在该模型系统中无需任何载体粉尘即可诱发呼吸道肿瘤。
