Fisher B, Wolmark N, Rubin H
J Natl Cancer Inst. 1976 Jul;57(1):225-6. doi: 10.1093/jnci/57.1.225.
Results of investigations employing [14C]cyclophosphamide (CY) demonstrated that even though total plasma radioactivity was similar in female C3HeB/FeJ mice treated either with CY alone or Corynebacterium parvum and CY, the proportion of total activity due to nonmetabolized CY was greater when C. parvum was used. These findings indicated that the antitumor effect of C. parvum may not have been entirely due to its immunopotentiating properties but may also have been related to its effect on the metabolism of CY.
采用[14C]环磷酰胺（CY）的研究结果表明，尽管单独使用CY或用短小棒状杆菌与CY联合处理的雌性C3HeB/FeJ小鼠的血浆总放射性相似，但当使用短小棒状杆菌时，未代谢CY在总活性中所占比例更大。这些发现表明，短小棒状杆菌的抗肿瘤作用可能并非完全归因于其免疫增强特性，还可能与其对CY代谢的影响有关。
