Purnell D M, Bartlett G L, Kreider J W, Biro T G, Kontra J
Cancer Res. 1979 Dec;39(12):4838-42.
The antitumor efficacy of various immune stimulants [Corynebacterium parvum, Bordetella pertussis, and Bacillus Calmette-Guérin (BCG)] and levamisole alone or in conjunction with cyclophosphamide (CY) was studied in the CaD2 mammary adenocarcinoma system using schedules developed previously with C. parvum and CY. Weekly systemic treatment with C. parvum, B. pertussis, or BCG was effective in controlling tumor growth and had equivalent antitumor effects, but weekly treatment (or a single treatment) with levamisole was ineffective. Weekly treatment with B. pertussis was better than treatment given only once, but repeated treatment with C. parvum or BCG was not more effective than a single treatment with these agents. When administered as a single systemic injection, C. parvum was superior to B. pertussis in controlling tumor growth, but a single systemic injection of BCG was as effective as C. parvum. Systemic administration of immune stimulants had variable effects on survival, which were sometimes not correlated with effects on tumor size. Combined treatment with BCG and CY was significantly more effective than CY treatment alone in controlling tumor growth in most trials, as was combination treatment with C. parvum and CY. Combination treatment with B. pertussis and CY was not better in prolonging survival than CY alone. Levamisole rarely improved the antitumor effect of CY chemotherapy and had no effect on survival compared to the effect of CY alone.
在CaD2乳腺腺癌系统中，使用先前针对短小棒状杆菌和环磷酰胺（CY）制定的方案，研究了各种免疫刺激剂[短小棒状杆菌、百日咳博德特氏菌和卡介苗（BCG）]以及左旋咪唑单独使用或与环磷酰胺联合使用的抗肿瘤效果。每周用短小棒状杆菌、百日咳博德特氏菌或卡介苗进行全身治疗可有效控制肿瘤生长，且具有同等的抗肿瘤作用，但每周用左旋咪唑治疗（或单次治疗）无效。每周用百日咳博德特氏菌治疗比仅单次治疗效果更好，但重复用短小棒状杆菌或卡介苗治疗并不比单次使用这些药物更有效。当作为单次全身注射给药时，短小棒状杆菌在控制肿瘤生长方面优于百日咳博德特氏菌，但单次全身注射卡介苗与短小棒状杆菌效果相同。全身给予免疫刺激剂对生存的影响各不相同，有时与对肿瘤大小的影响不相关。在大多数试验中，卡介苗与CY联合治疗在控制肿瘤生长方面明显比单独使用CY治疗更有效，短小棒状杆菌与CY联合治疗也是如此。百日咳博德特氏菌与CY联合治疗在延长生存期方面并不比单独使用CY更好。左旋咪唑很少能提高CY化疗的抗肿瘤效果，与单独使用CY相比，对生存没有影响。
