Delsmann B M, Lienemann A, Nerlich A, Hoffmann E, Caselmann W H, Refior H J
Orthopädische Klinik und Poliklinik, Ludwig-Maximilians-Universität München-Klinikum Grosshadern.
Z Orthop Ihre Grenzgeb. 1998 Nov-Dec;136(6):571-3. doi: 10.1055/s-2008-1045189.
Osseous metastases to the hand are very rare. Only a single case of osseous metastasis of hepatocellular carcinoma to the hand has been reported in the literature to date. We report a case of osteolytic metastasis of the right first metacarpal as first manifestation of unresectable, alpha-fetoprotein-negative hepatocellular carcinoma (pT3, Nx, M1, UICC stage IVB, Okuda's stage I). The therapy consisted of R0-resection and hormonal therapy with tamoxifen 2 x 10 mg/d orally. Generally patients with metastatic cancer to the bones of the hand have a very poor prognosis.
手部骨转移非常罕见。迄今为止，文献中仅报道过1例肝细胞癌手部骨转移病例。我们报告1例右第一掌骨溶骨性转移病例，该病例为不可切除的甲胎蛋白阴性肝细胞癌（pT3，Nx，M1，UICC IVB期，奥田分期I期）的首发表现。治疗方法包括R0切除及口服他莫昔芬（2×10mg/d）进行激素治疗。一般来说，手部骨骼发生转移性癌的患者预后很差。
